COVID-19 has become a major challenge to policymaking. In a context of high uncertainty, rapidly changing circumstances and a highly fluid base of evidence and scientifically-grounded predictions – policy-makers have to take decisions on which human lives and the economy depend. Using ideas and constructs from modern decision theory, the authors of this paper propose ways to arrive at decisions that remain valid for a wide range of futures and keep options open, while allowing for a responsible and transparent policy-making process.